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IIP-Pasteur Institute, Department of Microbiology
Paris, France (Outgoing Program)
Program Terms: Summer
This program is currently not accepting applications.
Partner Institution/Organization Homepage: Click to visit
Restrictions: Princeton applicants only
Fact Sheet:
Dept Offering Program: IIP, International Internship Program (IIP) Program Type: Internship
Language Prerequisite: No Program Features: Lab Based Work, Research
Degree Level: 2 First year Ugrad, 3 Sophomore, 4 Junior Time Away: Summer
Housing options: Student Responsibilty with support from IIP and/or Host Organization Program Group: International Internship Program
Program Description:
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About:  Since its creation in 1887, the Institut Pasteur has become famous throughout the world as a symbol of science and French culture. For 120 years, its foundation has contributed to the prevention and treatment of infectious diseases through research, teaching, and public health initiatives. The Institute enjoys an independent status and has numerous other assets, with its research laboratories, technological platforms, teaching center, and medical center all located on one campus in the heart of Paris.

Intern Responsibilities: The laboratory in which the IIP intern will be placed is interested in deciphering the molecular and cellular mechanisms of bacterial invasion of host cells. The host laboratory has developed several novel approaches to investigate the intimate interactions between the host and invading pathogens in single cells in space and in real time developing novel microscopic techniques. They employ their innovative, single-cell based, microscopic approaches to elucidate the apparent contradictory effects of multiple secreted effector proteins processes. The IIP intern will participate full-time in this ongoing research project in molecular genetics.

Qualifications: IIP candidates with interests in biochemistry, cell biology, biophysics, microbiology and immunology are encouraged to apply. Basic French would be an asset but is not required.

Previous work experiences (in the words of past IIP interns): Intern #1: I worked on a project studying the immunological effects of mutant Shigella bacteria on the infected and bystander human cells during infection. Intern #2: I conducted a series of small projects whose aims are as follow:1.To identify and characterize large vacuole structures in infected CHIKV cells. 2.To live image cells transfected with labeled CHIKV to deduce the functionality of the virus' capsid after subjection to such modifications. 3.To measure the RNA levels of specific genes in CHIKV infected fibroblast cells to determine the role of fibroblasts in activating the Th17 pathway...I learned how to do specific scientific techniques, how to design experiments and how to read scientific literature. Intern #3: My supervisor worked on a project to elucidate the first steps of Shigella infection into epithelial cells by using a quasi-physiological in vitro model that simulates two types of cells (M cells and enterocytes) in the intestine. Two projects that we were working on are finding a good immunofluorescence marker to characterize M cells and transducing cells with fluorescent actin to mark their cytoskeleton and visualize bacterial entry. Day-to-day responsibilities included maintaining cells, culturing bacteria, infecting cells, fixing and staining cells, and acquiring images using microscopes...I felt that I have learned a great deal from this internship. Firstly, techniques—I have never worked with eukaryotic cells or transwells, performed infections, done immunofluorescence staining, or used these kinds of microscopes. Secondly, I learned about lab dynamics and the atmosphere in a research institution. Third, I gained insight on different parts of an academic career since we have master's students, doctoral students, postdocs, and our PI in the lab. Fourth, I learned something about confidence in this kind of work and what kinds of setbacks to expect. Intern #4: My supervisor worked on a project to elucidate the first steps of Shigella infection into epithelial cells by using a quasi-physiological in vitro model that simulates two types of cells (M cells and enterocytes) in the intestine. Two projects that we were working on are finding a good immunofluorescence marker to characterize M cells and transducing cells with fluorescent actin to mark their cytoskeleton and visualize bacterial entry. Day-to-day responsibilities included maintaining cells, culturing bacteria, infecting cells, fixing and staining cells, and acquiring images using microscopes.  I felt that I learned a great deal from this internship. Firstly, techniques—I had never worked with eukaryotic cells or transwells, performed infections, done immunofluorescence staining, or used these kinds of microscopes. Secondly, I learned about lab dynamics and the atmosphere in a research institution. Third, I gained insight on different parts of an academic career since we have master's students, doctoral students, postdocs, and our PI in the lab. Fourth, I think I have learned something about confidence in this kind of work and what kinds of setbacks to expect.

View PowerPoint presentations by a past interns:
Robertson-Lavalle, Sophia, Pasteur Institute, France.ppt
Pasteur Institute, France, Ma, Helena.pdf
Pasteur, Paris, Grell, Yendé.pdf


 

Dates / Deadlines:
This program is not currently accepting applications. Please consult the sponsoring department's website for application open dates.
 
This program is currently not accepting applications.